Aldosterone antagonism and hypertension

Aldosterone antagonism attenuates obesity-induced hypertension and glomerular hyperfiltration.

This study examined the importance of aldosterone (ALDO) in mediating changes in renal function and increased mean arterial pressure (MAP) during the development of dietary-induced obesity in chronically instrumented dogs. Mean arterial pressure, heart rate (HR), and cardiac output (CO) were recorded 24 hours per day in lean dogs (n=7) before and after administration of an ALDO antagonist, eple...

Aldosterone receptor antagonism normalizes vascular function in liquorice-induced hypertension.

The enzyme 11beta-hydroxysteroid dehydrogenase (11beta-HSD2) provides mineralocorticoid receptor specificity for aldosterone by metabolizing glucocorticoids to their receptor-inactive 11-dehydro derivatives. The present study investigated the effects of the aldosterone receptor antagonists spironolactone and eplerenone on endothelial function in liquorice-induced hypertension. Glycyrrhizic acid...

Aldosterone Antagonism and Arterial Stiffness

To the Editor: We wish to congratulate White et al1 for their evaluation of the effects of the comparative aldosterone blocker eplerenone versus the calcium antagonist amlodipine in old subjects with systolic hypertension. Until recently, eplerenone was presented as a standard antihypertensive agent, acting mainly on diastolic blood pressure, but with limited affinity for the progesterone and a...

Aldosterone antagonism in heart failure

Aldosterone, a neurohormone known to affect electrolytes, has recently been implicated as playing a major role in the progression of heart failure, particularly in patients with systolic dysfunction. Major clinical trials designed to analyze clinical outcomes using an aldosterone antagonist have been done in two groups with heart failure. The first was the Randomized Aldactone Evaluation Study,...

Aldosterone antagonism by 17-spirolactosteroids.